Jannik Sinner will seek to clash with Andrey Rublev on Monday, while Russian star Mirra Andreeva will face the batsman, while former and both- and-deputy Daria Kasatkina takes a spot in the French Open quarterfinals.
Elsewhere, the world's No. 2 Coco Gauff will meet with Ekaterina Alexandrova in his last 16 and 24-time Grand Slam champion Novak Djokovic and Cameron Norrie's renewal.
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The third seeds, Alexander Zverev and Jessica Pegula, will also take the fourth round of action against Tallon Griekspoor and Lois Boisson respectively.
The Italian sinner will continue his pursuit to make it three consecutive Grand Slam titles when he accepted the 17th seed of Russia.
The two met nine times in their careers, with Sinner taking the edge with a six-win win, but the former world ranked fifth, with a winner at the only meeting of Roland Garros in the same stage in 2022.
Sinner retired from that encounter, but should have won Monday’s headline match in Fine Nick’s title match as he has so far limited his time on the court, winning all games in a row.
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However, his opponent spent less time playing in the third round of the walk through France's Arthur Fils.
"I have to be very careful. Andrey is an incredible player. I have to focus. He has a break. So let's see what's going to happen."
Teenager Andreeva will meet with Kasatkina - ranked 17 after allegiance from her native Russia and now plays for Australia.
The sixth time seed said, “I’ve practiced here with her, so I think we practiced every game together.”
"Of course, it's going to be an interesting game because I think we know each other very well. So, I think it's going to be... very tight."
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The 18-year-old lost a meeting with Kasatkina in the final last year in Nyingbo.
- "Let's go to Las Vegas' -
Djokovic, a three-time French Open champion, will have a chance to win 100 wins at Roland Garros when he faces Norrie in England.
The 38-year-old Serb had the least success in his title with a 99-16 victory/loss record.
"In terms of my longevity, it's just my statistics, especially over the past five to seven years, I look forward to expanding my career."
"As long as you're old, try to compete at the highest level. That's what happened, so I can't be happier than that."
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Djokovic ranked 81st in three sets in the red dirt in Geneva earlier this month to secure a century of ATP title.
Norrie's fellow countryman and the fifth seed of the man Jack Draper can extend his best at the French Open by defeating rejuvenating Alexander Bublik in the fourth round.
The Kazakhs are also enjoying his best performance at Roland Garros and crediting his return performance in recent months to a booming trip to Las Vegas with the coach.
“He (Bublik’s coach) is like, ‘Man, if you play like that, we’re not going to be tennis anymore, Wimbledon’s conversation’,” the top 20 player said.
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“I said, ‘Okay, let’s go to Las Vegas’.
“Las Vegas, Las Vegas, like a Hangover Man (2009 movie) Las Vegas, yes.”
Last year's German runner-up Zverev completed the men's fourth round when he took over as unseeded Dutchman Griekspoor.
Gauff has led the American Women's Quartet in the last 16 matches, the former finalist has fought Russian No. 20 seed Alexandrova, who made his first second week in Paris.
Australian Open champion and seventh seed Madison Keys competed with 70th-ranked compatriot Hailey Baptiste.
U.S. Open finalist Pegula will face 361 Boisson - the remaining French players and the lowest ranked competitor.
"Obviously... (Boisson's) will get some crazy support," said the 2024 U.S. Open finalist.
"I think it'll be fun. It'll be cool to be a part of it."
NF/JC