WASHINGTON — The Republican-led Senate hopes to hit the ground running on Monday and begin confirming President Donald Trump's nominees on his first day in office.

Republican leaders will seek unanimous consent from senators to hold a floor vote on one or more Trump administration picks. If granted expedited consideration, each nominee would receive 51 votes to be confirmed.

"We have a job to do, and advice and consent is part of that. So we're going to take that role seriously. Our senators, Republicans and Democrats, are going to take this role seriously, and we will," said Senate Majority Leader John Thune, R-S.D., said Monday on the "Today" show. "But we also understand that we have work to do, and I think voters made that clear in November."

When the House bangs the gavel at 4:30 p.m. ET, five nominees will receive votes from the committees overseeing confirmation hearings: Marco Rubio, secretary of state on the Foreign Relations Committee; Marco Rubio serves as Secretary of State on the Foreign Relations Committee; John Ratcliffe serves as Director of the CIA Intelligence Committee; Pete Hegseth serves as Secretary of Defense on the Armed Services Committee; Russell Vought Russell Vought as White House Budget Director, and Kristi Noem as Homeland Security Secretary on the Committee on Homeland Security and Government.

Nominees who receive a majority vote in the committee will be sent to the plenary session. From that point forward, all senators will reach an agreement that would allow for a floor vote on any one of them on Monday. There are a few candidates who could meet that criteria, most notably Rubio and Ratcliffe. But this is not guaranteed.

For Trump's more controversial picks, such as Hegseth, such an agreement to hold a floor vote is unlikely to be possible. Even if he gets the committee's approval, it could take days for him to confirm.

The Senate has a tradition of prioritizing votes on national security nominees under new administrations.

Every new president since Bill Clinton has confirmed at least one Cabinet nominee on Inauguration Day.

On January 20, 2021, then-President Joe Biden nominated Avril Haines to serve as Director of National Intelligence. On January 20, 2017, several Trump nominees were confirmed, including Secretary of Homeland Security John Kelly.

The first bill in the Senate on Monday will be a vote at 5:30 p.m. ET on the Laken Riley Act, a bill aimed at combating crimes related to theft by illegal immigrants in the United States.

The Senate is likely to meet for several hours afterward to confirm nominees who have sufficient support.

Ultimately, Thune predicts that all of Trump's choices will be confirmed.

"I think they all have a path to get there," he said. "Now, some people haven't had their confirmation hearings yet, so I always reserve judgment until they leave the committee because that's where they face tough questions. I think it's important that this process unfolds, and I guarantee it's a A fair process.”