NVIDIA boss Jensen Huang exploded U.S. regulations that blocked exports of advanced computing chips to China, believing they were opposed to U.S. companies.
He called the policy a “failure” at a press conference at the annual calculation conference in Taipei, Taiwan.
His comment comes days after the Trump administration said it would block Chinese exports altogether and limit sales to dozens of other countries.
The measures were announced in the last few days of Joe Biden's presidency, causing a fierce push from tech companies including Nvidia.
During Trump's first term, the United States began exerting control over semiconductor-related exports, citing fears that technology for potential military uses would fall into the hands of companies linked to the Chinese government.
Biden's drug delivery can significantly tighten restrictions.
Mr Huang said on Tuesday that during Biden’s four-year tenure, Nvidia’s share in the Chinese market fell from 95% to 50%.
He believes that these restrictions have prompted Chinese companies to move towards local alternatives and have inspired Chinese investment in the industry.
"First of all, the basic assumptions that led to the AI proliferation rules from the outset have proven to be fundamentally flawed," he told reporters.
Mr Huang's comments reflect on the ongoing debate in the United States on how to balance global business interests with economic and national security issues in the context of tensions with China.
Despite opposition from business groups, Trump was the first to promote trade tariffs.
But he took a more hybrid approach to the tech industry, from which he gained significant support in his reelection campaign last year.
The decision to abandon the broadest Biden-era rules will help promote AI deals between companies such as NVIDIA and countries including Saudi Arabia.
But the White House has tightened restrictions in other ways, banning U.S. companies from selling advanced technology to dozens of new companies, mainly from China.
Last month, the Commerce Department said it would impose new licensing requirements on certain NVIDIA chip exports.
It said it intends to replace Biden-era restrictions with its own method.
It also recently issued an alert to U.S. companies warning them of using Huawei chips to risk violating U.S. rules.
Beijing has since opposed the move, accusing the United States of a framework agreed upon in trade talks held in Switzerland earlier this month.