A gunman shot and killed two senior aides to Mexico's mayor Clara Brugada.

The mayor's personal secretary Ximena Guzmán and Brugada's adviser José Muñoz were killed while working on Tuesday morning local time.

Witnesses said an armed officer first opened fire at Guzmán, who had stopped by the busy avenue to pick up her colleagues and then in Muñoz, who was about to commute in the morning.

The gunman is believed to have escaped from the motorcycle with at least one accomplice. The possible motive for the killing remains unknown, but the attack is the latest in a series of murders committed by local politicians across the country.

Mayor Brugada was obviously upset at the press conference when she recalled how she shared her dreams and struggles with her two assistants during the years she worked for her.

She said she would make sure that the murders were not punished.

Security Minister Omar García Harfuch was informed of the shooting at a daily morning press conference, and Omar García Harfuch was once the target of armed ambush in the past.

President Sheinbaum described it as a "tragic event" and provided Mayor Brugada with the moderator of the same party as the president, all the support she might need.

Police caught the motorcycle and another car they believed were used in the attack, while forensic experts examined Guzman's bullet-type car.

CCTV footage of nearby buildings shows a man holding a motorcycle helmet in one hand and a gun in the other, approaching Guzman's car from the front.

He fired through the windshield, then shot Muñoz, and then fired at Guzman again.

As he ran away, he turned and shot Muniz, who broke down on the sidewalk.

Brugada, 61, was elected Mexico City Mayor in June last year. The position is considered the second strongest position in the country, second only to the president.

Although local politicians, especially the mayors of small towns, are often targeted by Mexico, attacks on politicians in the capital are even more unusual.

A notable exception is the 2020 ambush by García Harfuch, who was then the chief of police in Mexico City.

More than twenty gunmen opened fire at his car, killing two of his bodyguards and a passerby in one of the most craziest attacks in the city.

García Harfuch was attacked three times but survived and continued to become Mexico's security minister in October last year.

He said the Jalisco new generation of cartels, one of Mexico's most powerful criminal groups, is behind the incident.

Investigators have not said they believed to be behind the murder of two aides on Tuesday, but security experts say the deliberate and precise way the gunman operates shows that he is a professional killer.