Paris - Defending champion Carlos Alcaraz entered the fourth round of the French Open after working 6-1, 6-3, 4-6, 6-4 at a Friday night meeting.

The second seed Spaniard never played the 33-year-old Bosnian Dzumhur, who never competed in any major competition.

"I suffered a lot today," Alkaraz said. So far, he has given up on two sets. "The first two sets were under control and then he started to go deeper and more active. It was really hard for me."

Dzumhur injured his left knee in a second round fall and was treated on his right leg during a transition of 3-2 down in the third set on Friday. Then he lay on the ground while the coach worked on both legs for a few minutes.

Philippe-Chatrier's crowd yelled "Olé" as she waited.

Dzumhur then won the third set again despite maintaining an uneven balance, and he received cheers again when he broke Alcaraz in the opening game of the fourth set.

As Alcaraz makes a clumsy, non-compulsory mistake, an impossible turn seems to have taken place. But the four-time Grand Slam champions broke the game in Games 6 and 8.

Despite this, the resilient Dzumhur ran hard on his face, his sweat glittering and broke the suspense for a longer time.

Alcaraz finally won his second match point and faced Ben Shelton in the fourth round.

Sheldon will make his 16-round debut in Roland Garros after defeating Matteo Gigante 6-3, 6-3, 6-4.

On Friday, Tommy Paul ranked 12th in five sets beat Karen Khachanov, while No. 15 Frances Tiafoe beat No. 23 Sebastian Korda 7-6 (6), 6-3, 6-4 In the All-American game, the United States will win three games in the fourth round in France for the first time since 1995.

If Ethan Quinn wins Saturday, there will be four American men in Paris in Week 2 since 1991.

Italy's No. 8 Lorenzo Musetti beat Mariano Navone and Denmark's No. 10 Holger Rune to French Quentin Halys in the third round of the other men on Friday.

Australia's Alexei Popyrin ranked 25th also ahead of schedule.

The Associated Press contributed to this report.